USES :

ENZAPROST® T is indicated for its luteolytic effects in cattle and pigs. The indications for use are: Cattle: 5 ml The luteolytic effect of ENZAPROST® T can be exerted in the following therapeutic uses:

1.  Oestrus synchronisation

2. Treatment of sub-oestrus or silent heat in cows which have a functional corpus luteum, but do not express behavioural oestrus.

3.  Induction of abortion until day 120 of pregnancy.

4.  Induction of parturition

5. For aid in the treatment of chronic metritis or pyometra where there is a functional or persistant corpus luteum.

DOSAGE AND ADMINISTRATION :

Administer via intramuscular injection. Full aseptic precautions should be taken. Use a sterile syringe and needle and make the injection through an area of clean skin. Care should be taken to avoid injection through wet or dirty areas of skin. Avoid the introduction of contamination during use. Should any apparent growth or discolouration occur the product should be discarded.

Cattle:

1. Oestrus synchronisation One administration of 25 mg of dinoprost (as trometamol), i.e. 5 ml of ENZAPROST® T per animal, to be repeated, if necessary after 11 (10 to 12) days. Animals treated during dioestrus will normally return to oestrus and ovulate within two to four days after treatment. Animals treated with ENZAPROST® T may be bred by natural service, artificial insemination on detected oestrus or at fixed time insemination (72 and 96 hours after the second injection is usually recommended).

2. Treatment of sub-oestrus or silent heat in cows which have a functional corpus luteum, but do not express behavioural oestrus. One administration of 25 mg of dinoprost (as trometamol), i.e. 5 ml of ENZAPROST® T per animal, to be repeated, if necessary after 11 (10 to 12) days.

3. Induction of abortion until day 120 of pregnancy One administration of 25 mg of dinoprost (as trometamol), i.e. 5 ml of ENZAPROST® T per animal. ENZAPROST® T may be used to terminate pregnancy in cattle until day 120 of pregnancy through its luteolytic effect.

4. Induction of parturition One administration of 25 mg of dinoprost (as trometamol), i.e. 5 ml of ENZAPROST® T per animal on or after day 270 of gestation. The interval from administration to parturition is one to eight days (average three days).

5. For aid in the treatment of chronic metritis or pyometra where there is a functional or persistent corpus luteum. One administration of 25 mg of dinoprost (as trometamol), i.e. 5 ml of ENZAPROST® T per animal, to be repeated, if necessary after 11 (10 to 12) days.

CONTRA-INDICATIONS, WARNINGS, ETC

Do not treat animals if they suffer from either acute or subacute disorders of the vascular system, gastro-intestinal tract or respiratory system. Do not administer to pregnant animals, unless it is desirable to induce parturition or interruption of pregnancy.

Special warnings for target species : 

No special warnings.

Undesirable effects (frequency and seriousness)

Cattle The most frequently observed side-effect is increased rectal temperature. However, the rectal temperature changes have been transient in all cases observed and have not been detrimental to the animal. Limited salivation has been seen in some instances. The side-effects disappear within one hour after the administration of PGF2a. In cattle, if used for induction of parturition, retained foetal membranes may occur more frequently, depending on the time of use of the product.

ENZAPROST® T is ineffective when administered prior to day 5 after ovulation. Localised post injection bacterial infections that may become generalised have been reported. Aggressive antibiotic therapy, particularly covering clostridial species, should be employed at the first sign of infection. Careful aseptic techniques should be employed to decrease the possibility of post injection bacterial infections. Do not administer by intravenous route. Induction of abortion or parturition by using exogenous substances may increase the risk for dystocia, foetal mortality, retention of the placenta and/or metritis.

Use during pregnancy and lactation Pregnancy status should be determined prior to injection since Dinoprost has been demonstrated to result in abortion or parturition induction when administered at sufficiently high doses in many animal species. If pregnant, the unlikely possibility of uterine rupture should be born in mind, especially if cervical dilation does not occur. Induction of parturition in pigs earlier than 72 hours prior to predicted farrowing date may result in reduced piglet viability.

Withdrawal periods

Cattle: Meat and offal: 3 days.

Milk: Zero hours