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Marbofloxacin is a synthetic, bactericidal antimicrobial

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Pharmacodynamic properties : Marbofloxacin is a synthetic, bactericidal antimicrobial, belonging to the fluoroquinolone group, which acts by inhibition of DNA gyrase. It has a broad-spectrum activity in vitro against a wide range of bacteria, particularly Gram-negative bacteria but also against Gram-positive bacteria. Pharmacokinetic particulars After a single intramuscular administration in cattle at the recommended dose of 8 mg/kg, the maximum plasma concentration of marbofloxacin (Cmax) is 8 µg/ml. Binding to plamsa proteins is about 30%. Marbofloxacin is eliminated slowly, predominantly in the active form in urine and faeces. After subcutaneous administration at the recommended dose of 2 mg/kg, marbofloxacin is readily absorbed and reaches maximal plasma concentrations of 1.7 µg/ml. Its bioavailability is close to 100%. Marbofloxacin is weakly bound to plasma proteins (30%), extensively distributed and in most tissues (liver, kidney, skin, lung, bladder, uterus) it achieves higher concentrations than in plasma. Marbofloxacin is eliminated predominantly in the active form in urine and faeces.


Cattle Therapeutic treatment of:

-Respiratory infections caused by sensitive strains of Pasteurella multocida, Mannheimia haemolytica, Histophilus somni and Mycoplasma bovis.

-Acute mastitis (cause by E. coli strains sensitive to marbofloxacin).

-Neonatal enteritis (due to E. coli and Salmonella).

- Metritis.


Do not use in animals with known hypersensitivity to fluoroquinolones. Do not use in cases where the pathogen involved is resistant to other fluoroquinolones.


Occasional transient inflammatory reaction at the injection site.


The recommended dosage is: Respiratory infections 8 mg/kg bodyweight i.e. 2 ml/25 kg bodyweight in a single injection by intramuscular route. Treatment of acute mastitis, neonatal enteritis and metritis 2 mg/kg bodyweight i.e. 1 ml/50 kg bodyweight in a single daily injection by subcutaneous route, for 3 consecutive days. The first injection may also be given by the intravenous route too. If the volume to be injected is more than 20 ml, it should be divided between two or more injection sites.


Intramuscular route: Meat and offal: 3 days - Milk: 72 hours. Subcutaneous route: Meat and offal: 6 days - Milk: 36 hours.


Store at temperature not exceeding 30°C away from light and to be used after opening for 28 days when stored at temperature not exceeding 25°C.

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